Biography
Graduated from the Kazan Federal University with a degree in physiology. For a given moment, I am graduated stydent from the Kazan Federal University in the laboratory of motor neurorehabilitation.
Abstract
Studies performed in conditions of a microgravity models and microgravity models with putting on animal's feet. All tests were conducted on nonlinear laboratory rats (180-200 g). As a model of gravitational unloading we used antiortostatic support model. All experiments were performed according to bioethical standards and were approved by local ethical committee of the Kazan Federal University. The femoral bones were dissected from all tested rats with following weight measurement, density evaluation, and measurement of geometrical parameters. At the end, the stress tests with a three-points bending were performed. After testing Young's module and ultimate stress was calculated. It was investigated different groups: control, microgravity models for 7 days of unloading hanging and models 7 days of unloading hanging with putting on animal's feet for 3 hour every day. In "hypogravitational" models Young's module decreased slightly, but ultimate stress decreased significantly. In case of putting on animal's feet Young's module restores its value (deviation about 5%) and ultimate stress increases up to 33% (in comparison with "hypogravitational" models). Against the background of control group ultimate stress decreased up to 45%. These results emphasize that the bone strength can be decreased by influence of external forces.
Biography
I have begun the scientific research in the field of fundamental medicine still being a student of the 2nd course of department of human and animal physiology, KFU. Since 2013, I am a part of the research group on the basis of Kazan Federal University which is engaged in development of methods of stimulation of neuroregeneration at such diseases as an injury of a spinal cord and an atrophy of skeletal muscles and bones. Since 2015, I`m graduate student of KFU.
Abstract
Studies performed that anisotropic properties of the bone tissue changes significantly in case of changing the activity. All tests were conducted on nonlinear laboratory rats (180-200 g). As a model of gravitational unloading we used antiortostatic support model. All experiments were performed according to bioethical standards and were approved by local ethical committee of the Kazan Federal University. The femoral bones and shoulder bones were dissected from all tested rats with following weight measurement, and measurement of geometrical parameters. Bones was scanned on μCT in diaphysis, metaphysis and epiphysis regions. After scanning the bone porosity was calculated. The structure of porosity medium was analyzed in terms of fabric tensor. It was investigated different groups: control and "hypogravitational" on different time of unloading hanging (7, 14, 21, 30 and 40 d). The result of anisotropic properties of diaphysis of the bone was as follows. Main stiffness directed in longitudinal direction. Structure of bone tissue looks like adaptive to bending with compression. Anisotropic properties of a femur changes after some period of unloading: main stiffness direction turns at an angle relative to longitudinal direction. The value of the angle increases in dependence of time of unloading. In transverse plane stiffness changes aspect ratio of stiffness in radial and tangent directions. These results emphasize that bone tissue in unloaded bones adapt to external forces and anisotropic properties of the tissue changes significantly.